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structure nameHUMAN MUTSALPHA (MSH2/MSH6) BOUND TO ADP AND A G T MISPAIR
(DNA MISMATCH REPAIR PROTEIN MSH6)
referencePohlhaus et al. Mol.Cell 26 579 2007
sourceHOMO SAPIENS
experimentX-ray (resolution=2.75, R-factor=0.245)
structural superfamilyP-loop containing nucleoside triphosphate hydrolases;DNA repair protein MutS, domain I;DNA repair protein MutS, domain III;
sequence familyMutS domain V; MutS domain I; MutS family domain IV; MutS domain III;
multimeric complexes2o8b_AB 2o8c_AB 2o8d_AB 2o8e_AB 2o8f_AB
redundant complexes2o8d_B 2o8e_B 2o8f_B 2o8c
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence

No structural evidence for specific binding to DNA (<4 informative columns)


Dendrogram of similar interfaces ?

matrix format
  
  VCKCFGETMT----PG--------                             +------2o8b_B    
                                              +--------3 
  --YGKA------SAPA--------                    !        ! +----3thx_B    
                                              !        +-1 
  MGDAFGTT--MC--PT--------       +------------4          +----1wb9_A    
                                 !            ! 
  ----FGET----------------       !            !         +-----1ewq_A    
                               --5            +---------2 
  --DGFG------VGSG--------       !                      +-----3thx_A    
                                 ! 
  ----------------WATAQGEC   L   +----------------------------7jn3_E    
                               

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updated Tue Dec 19 06:46:06 2023