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legend  pdf

structure nameRETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
(PROTEIN THYROID HORMONE RECEPTOR)
referenceRastinejad et al. Nature 375 203 1995
sourceHOMO SAPIENS
experimentX-ray (resolution=1.90, R-factor=0.206)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2nll_AB 3m9e_AB 3m9e_EF
redundant complexes3m9e_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRRK

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5 specificity:   
A |   0   0  13   0  54
C |   0   0  16  96  13
G |  96  96  13   0  13
T |   0   0  54   0  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----EA--KG--RTRG------   L                 +-----1kb2_B    
                                         +--10  
  ----EC--KG--KTRG------   L             !   +-----2nll_A    
                                     +--11  
  --HGECAGKGAAKGRT------   L         !   !     +---1lo1_A    
                                     !   !     ! 
  ----EC--KG--KGRG------   L         !   +-----8    +1ynw_B    
                                     !         !  +-5 
  --------KGVT--RG------   L         !         +--6 +5cbz_E    
                               +----13            ! 
  ----EC--KG--RGRG--FT--   L   !     !            +3dzy_D    
                               !     !  
  ----EA--KG--RTRTRT----       !     !             +4umm_E    
                               !     !   +---------1 
  ----EA--KG--RTRTRT----       !     !   !         +2han_B    
                               !     +--12  
  CA--EC--KG--KGRG----RT   L   !         !     +---6l6q_B    
                               !         !     ! 
  ----DG--KG--RTRG------   L -14         +-----9   +3cbb_A    
                               !               ! +-2 
  ----EC--KG--KGRG------   L   !               ! ! +2ff0_A    
                               !               +-7 
  --------KAVA--RA------   L   !                 !   +5e69_A    
                               !                 ! +-3 
  ----EC--KG--KGRG------       !                 +-4 +3dzy_A    
                               !                   ! 
  ----ET--KGAT--RG------   L   !                   +1lat_A    
                               !  
  --------KGVT--RG------       +-------------------5emp_A    
                             

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updated Tue Dec 19 06:43:36 2023