interface graph thumbnail
legend  pdf

structure nameAART, A SIX FINGER ZINC FINGER DESIGNED TO RECOGNIZE ANN TRIPLETS
(AART)
referenceBarbas III et al. J.Mol.Biol. 363 405 2006
sourceMUS MUSCULUS
experimentX-ray (resolution=1.96, R-factor=0.203)
structural superfamilyC2H2 and C2HC zinc fingers;
sequence familyZinc finger, C2H2 type; Domain of unknown function DUF1610;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRDHKDRQRANQAHRDNTRRDA

Estimated binding specificities ?

readout + contactlogo
# IC=21.430 IC/col=1.191 n_of_columns=18 specificity:   
A |  10   0   0  96   0   0   0  96  96  96  96   0  10   0   0   0   0   0
C |  12   0   0   0   0   0   0   0   0   0   0   0  66  85  96   0   0   0
G |  10  96  11   0  96  96  96   0   0   0   0  96  10   0   0  96  96  96
T |  64   0  85   0   0   0   0   0   0   0   0   0  10  11   0   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  CTSTQT--LTITST--STHTRG----RG----EA--RA----TTTGEC--RG----RG----ET--------RG--SCEC--RG   L      +-----------------------------5v3j_F    
                                                                                             +-25  
  --SGHG--RGRGDC--SCHG------DC--SANA------WC--SCVG--RG----DC--SGNA------------STHG--RG   L   !  +-----------------------------5v3g_A    
                                                                                             !  
  RGDCHG----------KGDCRG----QARGATNA------QA--ATHG--------RG--DCNA----TT--RGRTDAAT----   L   !                                                      +--2i13_A    
                                                                                             !                                       +--------------4 
  TTTCLA------TTSC--ECRGYG--EC--SCKG--RG--DG--YCKG--RG--TCQA----TC--------RA--SCDC----   L   !                                   +--10              +--5t0u_A    
                                                                                             !                                   !   !  
  ------RGYG--EC--SCKGRG------TCYCKA--RGTCQAST--TC--------RC--SCDC----VT--------------   L   !                                   !   +-----------------5yef_B    
                                                                                             !                                +-12  
  ----------------SA--MT----VT----NA--RG------ETTG--------YG--ST----------------------       !                                !  !    +----------------6e94_A    
                                                                                             !                                !  +----9 
  ------------NG--SGHGRG----DA--SCHG--RGRGDC--SCNA--------NCKTSAHG----RG--------------   L   !                             +-13       !                +5ei9_F    
                                                                                             !                             !  !       +----------------1 
  ------------EC--SGKGRG----DG--YCKG--RG--QA----TC--------RA--SCDC----VT--------------   L   !                             !  !                        +5k5h_A    
                                                                                             !                          +-15  !  
  ----------------TCSGRG----LT--ETYC------NTYGQG--------------------------------------   L   !                          !  !  +-----------------------6dfb_A    
                                                                                             !                          !  !  
  ----------FT----KAYT------WT--WTST--ET--FTVASGDC--SA--------------------------------   L   !                          !  +------------------------6jnm_A    
                                                                                             !                          !  
  --------------------KT----EC--SCKG--RG--LT--FCNA--------QA--TTNA--------------------   L   !                       +-16                     +----1ubd_C    
                                                                                             !                       !  !  +------------------5 
  ------------EC--SCKGRG------TCYCKA--RG--QA----TC--------RA--SCDC----VT--------------       !                       !  !  !                  +----5yeg_A    
                                                                                             !                       !  !  !  
  --------------------------QA--TCNA------QAHTTT----QA----TTLAHGTC--DTRG--------------   L   !                       !  !  !                      +1g2d_F    
                                                                                           -26                       !  +-14                 +----2 
  --------------------------AT--YC--------RA----NC----------ATSGDC----KG--DCPTSGSARTKG   L   !                       !     !         +-------6    +2gli_A    
                                                                                             !                       !     !         !       ! 
  ----------NGKT--WTKG----------HTHG--RGTGTT--ACNA--KGRG------------------------------   L   !                    +-17     !    +----8       +-----1tf3_A    
                                                                                             !                    !  !     !    !    ! 
  ------------RGSTDAHARG----RGSTDCHG--TT--RG--DAEG--RG--------------------------------   L   !                    !  !     +---11    +-------------5kl3_A    
                                                                                             !                    !  !          !  
  ------------------------FARGSGSCTC--TAHCQA--STDC--KT----QASGSANA--IGTT--------------   L   !                    !  !          !                +-2kmk_A    
                                                                                             !                 +-18  !          +----------------3 
  KGWTKA----------HCHGRG----TA--ACNA--KG----------------------------------------------   L   !                 !  !  !                           +-1tf6_A    
                                                                                             !                 !  !  !  
  ----------------------------------------------YG--------WT--WTST----ET--FTVASGDCSART   L   !                 !  !  +--------------------------6a57_A    
                                                                                             !              +-19  !  
  --------------------------DC--SCQG--KTTTAT--SCSC--------DC--SGAT--RARG--RG--DCNA----   L   !              !  !  !                +-----------6ml4_A    
                                                                                             !              !  !  +----------------7 
  ------------DC--YCKGRG----QA----TC------RC--SCDC--VT--------------------------------   L   !           +-20  !                   +-----------5k5i_A    
                                                                                             !           !  !  !  
  --------------------------QA--TTNA----STQAQTATSTNTAT----TTLAHGTC----RG--------------   L   !           !  !  +----------------------------1g2f_F    
                                                                                             !        +-21  !  
  --------------------------RGSTDTEG--RG--RGSGDCHG--TT----RG--DAEG----RG--------------   L   !        !  !  +----------------------------4x9j_A    
                                                                                             !     +-22  !  
  ECSCKG--RG--DCTCYCKGRG----QA----TC------RC--SCDC--VT--------------------------------   L   !     !  !  +----------------------------5und_A    
                                                                                             !  +-23  !  
  --------------------------QA--SGNA--KG--QASTSCDC--KG----RG--DCHA----RG--------------   L   !  !  !  +----------------------------1mey_C    
                                                                                             +-24  !  
  ----------------------------------------QG--RGHT--MG----QG----LGLC----TTRG----------   L      !  +----------------------------5yel_A    
                                                                                                !  
  ----------RGST--YGYC------QC--TGSTRAYT----------------------------------------------   L      +-----------------------------3uk3_C    
                                                                                           

home
updated Tue Dec 19 06:35:22 2023