| structure name | PHAGE-SELECTED HOMEODOMAIN BOUND TO UNMODIFIED DNA (Segmentation polarity homeobox protein engrailed) |
| reference | Feldman et al. 'Acs 1 755 2006 |
| source | Drosophila melanogaster |
| experiment | X-ray (resolution=1.90, R-factor=0.225) |
| structural superfamily | Homeodomain-like; |
| sequence family | Homeobox domain; |
| multimeric complexes | 2hos_AB 2hot_AB |
| redundant complexes |  2hot_A
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | RKN |
Estimated binding specificities ?
| readout + contact |  |
A | 8 0 72 0 8 88 C | 11 0 8 0 11 0 G | 69 96 8 0 8 8 T | 8 0 8 96 69 0scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: ENGRAILED | ||
| TAATTA | PubMed | 2hos_A(1.21e-03), 2hot_A(3.57e-04) |
| TAATCC | PubMed | 2hos_A(4.53e-11), 2hos_AB(6.43e-08), 2hot_AB(5.23e-08), ... (total=4) |
| CGCATCCCC | PubMed | 2hos_A(1.05e-02) |
| TTAATT | PubMed | 2hos_A(1.21e-03), 2hot_A(3.57e-04) |
| TAATNN | PubMed | 2hos_A(1.21e-03), 2hot_A(3.57e-04) |
Dendrogram of similar interfaces ?
matrix format------YA----------IAQCNAYCKG-- L +---------------------------5flv_I ! ------------------NT--NAIARG-- L ! +1b72_B ! +---4 ------------------NT--NAITRG-- L ! +--------7 +5zjt_B ! ! ! ------------------ITQTNAMG---- L ! +-10 +----5zjt_E ! ! ! ------------------IA--NA------ ! ! ! +4qtr_D -15 +-----11 +-------------3 ------------------ITQCNAACRG-- L ! ! ! +6a8r_A ! +-13 ! ------------RTQT--ITQANAVTKTKT L ! ! ! +---------------2ld5_A ! ! ! ----------YTVC--KGDCKC-------- L ! ! +----------------------2qhb_A ! ! ------------------IAKGNA------ L ! ! +2hdd_A ! ! +-1 ----------------KTIAQCNA----RT L ! ! ! +1ig7_A +-14 +-------5 ------------------NT--NA--RG-- L ! ! ! +1b8i_B ! +---8 +-2 ------------------NCITNARGRG-- L ! ! ! +6fqq_E ! +-----9 ! ----------------KGSAQA-------- L ! ! ! +--------6j5b_C ! ! ! NGRGTG--LG--LCRG-------------- +----12 +------------4e9f_A ! ----------STVC--KGDCRG-------- L ! +--1w0t_A +---------------6 --------------NTTCTA---------- L +--5zux_A |
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updated Tue Dec 19 06:33:24 2023