interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HETERODIMERIC L. DONOVANI TOPOISOMERASE I- VANADATE-DNA COMPLEX
(TOPOISOMERASE I-LIKE PROTEIN)
referenceDavies et al. J.Mol.Biol. 357 1202 2006
sourceLEISHMANIA DONOVANI
experimentX-ray (resolution=2.27, R-factor=0.233)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
multimeric complexes2b9s_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKNRMYMKNKDT

Estimated binding specificities ?

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# IC=6.105 IC/col=0.872 n_of_columns=7 specificity:   
A |   0  15  80  90   5   0   0
C |  96  10   6   0  20   0  85
G |   0  21   5   0  66   0   6
T |   0  50   5   6   5  96   5
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KANT--RGMGYAMCKT--NCKTDA------TT--   L                              +-2b9s_A    
                                               +----------------------1 
  ----ECRA--YAMCKT--NTKT------------       +---2                      +-1k4t_A    
                                           !   ! 
  ----------------RG------RG--------   L --3   +------------------------3m4a_A    
                                           ! 
  --------------------------TTQAYAKT   L   +----------------------------5jk0_B    
                                         

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updated Tue Dec 19 06:21:15 2023