interface graph thumbnail
legend  pdf

structure nameHTRF1 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA.
(TELOMERIC REPEAT BINDING FACTOR 1)
referenceChapman et al. 'Embo 6 39 2005
sourceHOMO SAPIENS
experimentX-ray (resolution=2.00, R-factor=0.252)
structural superfamilyHomeodomain-like;
sequence familyMyblike DNAbinding domain;
multimeric complexes1w0t_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSVKDR

Estimated binding specificities ?

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# IC=4.087 IC/col=0.817 n_of_columns=5 specificity:   
A |   0   0   0  12  10
C |   0   0  12  10  10
G |  96  96  74  10  12
T |   0   0  10  64  64
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HTRF1
TTAGGGPubMed1w0t_AB(1.77e-04)
TTTAGGGPubMed1w0t_AB(1.69e-03)
GGTTTAGPubMed1w0t_A(1.05e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----------YTVC--KGDCKC----   L   +----------------------------2qhb_A    
                                   !  
  RT--------STVTMCKGDCRGTA--   L   !                            +1iv6_A    
                                   !            +---------------1 
  RA----------------ITQTNAMG   L   !      +-----7               +5zjt_E    
                                   !      !     ! 
  RA----YA----------IAQCNAYC   L   !   +-10     +---------------5flv_I    
                                 -13   !  !  
  ------------KG--RTEC------   L   !   !  +---------------------1h89_C    
                                   !   !  
  RT--------------KTIAQCNA--   L   !   !                       +-1ig7_A    
                                   !   !               +-------4 
  ------------------IA--NA--       !   !               !       +-4qtr_D    
                                   !   !         +-----6 
  RT--------STVC--KGDCRG----   L   +--12         !     !         +1w0t_A    
                                       !         !     +---------2 
  RA--------------KGSAQA----   L       !       +-8               +6j5b_C    
                                       !       ! ! 
  RT----------------IAKGNA--   L       !       ! !               +2hdd_A    
                                       !  +----9 +---------------3 
  ------------RTQT--ITQANAVT   L       !  !    !                 +2ld5_A    
                                       !  !    ! 
  --AT----NT--TCTA----------   L       +-11    +----------------5zux_A    
                                          !  
  ----MG--TGQAAT--SARG------   L          !                  +--2p5l_D    
                                          +------------------5 
  ------DT--RGRCTT--KT------   L                             +--2o9l_A    
                                 

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updated Tue Dec 19 06:13:42 2023