interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF AN IDER-DNA COMPLEX REVEALS A CONFORMATIONAL CHANGE IN ACTIVATED IDER FOR BASE-SPECIFIC INTERACTIONS
(Iron-dependent repressor ideR)
referenceWisedchaisri et al. J.Mol.Biol. 342 1155 2004
sourceMycobacterium tuberculosis
experimentX-ray (resolution=2.75, R-factor=0.232)
structural superfamilyIron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;C-terminal domain of transcriptional repressors;
sequence familyIron dependent repressor, metal bindin; Iron dependent repressor, Nterminal D; FeoA domain; MarR family;
multimeric complexes1u8r_ABCD 1u8r_GHIJ
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSPTSQR

Estimated binding specificities ?

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# IC=5.032 IC/col=0.839 n_of_columns=6 specificity:   
A |   2  17  96  19   0   0
C |   8  17   0  17   0   0
G |   8   8   0  43  96  96
T |  78  54   0  17   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------ST--PTTCSTQC--RC----   L            +-------------------1u8r_B    
                                          +-----4 
  RGRTKG--------------------YGKC   L      !     +-------------------6lui_A    
                                          ! 
  ----------------------YG------          !                        +2heo_D    
                                       +--6                +-------1 
  ------SGQG--YCNC--------------       !  !        +-------2       +2ve9_C    
                                       !  !        !       ! 
  --------------TTHT--KG--------   L   !  !  +-----3       +--------7b0c_A    
                                     --7  !  !     ! 
  ------TC--STKTPTTTFT----------       !  +--5     +----------------4ass_H    
                                       !     ! 
  ----------DCLT--AGTTRG--RG----   L   !     +----------------------5h3r_A    
                                       ! 
  --------------------------RT--       +----------------------------3gfi_A    
                                     

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updated Tue Dec 19 06:12:39 2023