interface graph thumbnail
legend  pdf

structure nameINTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA
(PROTEIN INTERFERON REGULATORY FACTOR 1)
referenceEscalante et al.
sourceMus musculus
experimentX-ray (resolution=3.00, R-factor=0.242)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes1if1_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHNRCNS

Estimated binding specificities ?

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# IC=5.163 IC/col=0.860 n_of_columns=6 specificity:   
A |   6  25   0  25   0  96
C |  85  20   0  15  96   0
G |   5   5   0  21   0   0
T |   0  46  96  35   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: IRF-1
GAAANNPubMed1if1_B(1.18e-03)
GAAAGTPubMed1if1_B(9.73e-07), 1if1_AB(1.42e-03)
GTAAAGAAAGTPubMed1if1_B(1.18e-04)
AAAGGAPubMed1if1_B(1.20e-03)
GAAAGPubMed1if1_B(1.34e-07)

Dendrogram of similar interfaces ?

matrix format
  
  ----NASTRGHT--ST--   L     +-----------------------------2uzk_A    
                           +-3 
  ----NASTRTHT--ST--   L   ! +-----------------------------3l2c_A    
                         --4 
  --KTRG----RGYA----   L   !                           +-4l18_B    
                           !                       +---1 
  --KTRG----RGYT----   L   +-----------------------2   +-4bqa_A    
                                                   ! 
  ECKTRGAT--RGHT--RA   L                           +-----4mhg_A

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updated Tue Dec 19 05:44:20 2023