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legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL
(PROTEIN TRANSCRIPTION FACTOR MAX)
referenceBrownlie et al. Structure 5 509 1997
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.213)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes1hlo_AB
reference complex5eyo_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHNLERR

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5 specificity:   
A |   0   0  54   0  13
C |  96  96  13  96  16
G |   0   0  16   0  54
T |   0   0  13   0  13
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MAX
CACGTGPubMed1hlo_B(4.51e-04), 1hlo_AB(8.29e-10)
CATGTGPubMed1hlo_AB(6.79e-05)
CANNTGPubMed1hlo_AB(3.37e-03)
CACATGPubMed1hlo_AB(6.79e-05)
AACGTTPubMed1hlo_AB(3.37e-03)
CACGCGPubMed1hlo_B(4.51e-04), 1hlo_AB(6.79e-05)
CAAGTGPubMed1hlo_AB(6.79e-05)
GACCACGTGGTCPubMed1hlo_B(1.83e-05), 1hlo_AB(1.35e-09)

Dendrogram of similar interfaces ?

matrix format
  
  KT----HGNT--ECRCRG   L       +-----------------------------1nkp_A    
                               ! 
  ------HGNT--ECRCRG   L       !             +----------------7d8t_A    
                             +-6     +-------2 
  ------HGNTMTEARCRG         ! ! +---4       +----------------1nlw_D    
                             ! ! !   ! 
  --NTRGEC--RC------         ! ! !   +------------------------2ql2_A    
                             ! +-5 
  ------RTNT--ECRCRG   L   +-7   !         +------------------4h10_B    
                           ! !   +---------3 
  ------HGSTITETRCRG   L   ! !             !                 +4h10_A    
                           ! !             +-----------------1 
  ------HG----ETRTRG     --8 !                               +5v0l_A    
                           ! ! 
  ------HG----ETRCRG   L   ! +-----------------------------5gnj_I    
                           ! 
  ----QG----VTECRCRG   L   +-----------------------------1an4_A

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updated Mon Dec 18 05:09:58 2023