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legend  pdf

structure nameDIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE
(DIPHTHERIA TOXIN REPRESSOR)
referenceMurphy et al. Biochemistry 39 10397 2000
sourceCorynebacterium diphtheriae
experimentX-ray (resolution=3.00, R-factor=0.245)
structural superfamily"Winged helix" DNA-binding domain;Iron-dependent repressor protein, dimerization domain;
sequence familyIron dependent repressor, Nterminal D; Iron dependent repressor, metal bindin; MarR family;
multimeric complexes1f5t_ABCD
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSPTQR

Estimated binding specificities ?

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# IC=2.635 IC/col=0.659 n_of_columns=4 specificity:   
A |  11   0   9   9
C |   9   0  67   9
G |  67  96  11  11
T |   9   0   9  67
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: DTXR
TTAGGTGAGACGCACCCATPubMed1f5t_ABCD(1.22e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RGRTKG------------------------YGKC   L     +-----------------------------6lui_A    
                                             ! 
  ------------------------YG--------         !                             +2heo_D    
                                             !                   +---------1 
  ------LT------RTSGTGQTRG----------   L     !             +-----2         +2xro_E    
                                           +-6             !     ! 
  ----------------TTHT--KG----RC----   L   ! !         +---3     +---------7b0c_A    
                                           ! !         !   ! 
  --------SGQG--YCNC----------------       ! !     +---4   +---------------2ve9_C    
                                         --7 !     !   ! 
  --------TC--STKTPTTTFT--------RT--       ! +-----5   +-------------------4ass_H    
                                           !       ! 
  ------------DCLT--AGTTRG--RG------   L   !       +-----------------------5h3r_A    
                                           ! 
  ------------------------------RT--       +-----------------------------3gfi_A    
                                         

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updated Tue Dec 19 05:37:29 2023