1efa_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF (LAC REPRESSOR)
reference	Bell et al.
source	Escherichia coli
experiment	X-ray (resolution=2.60, R-factor=0.247)
structural superfamily	Periplasmic binding protein-like I;lambda repressor-like DNA-binding domains;
sequence family	Bacterial regulatory proteins, lacI fami; Periplasmic binding proteins and sugar b;
multimeric complexes	1efa_AB 1jwl_AB 1lbg_AB 1lbg_CD 2pe5_AB
redundant complexes	1jwl_B 1lbg_D 2pe5_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1efa_B interface=5,6,15,16,17,20,21,28,52,55,56, kpvtLYdvaeyagvSYQtvSRvvnqasHvsaktrekveaamaelnyipnrvAqqLAgkqslligvatsslalhapsqivaaiksradqlgasvvvsmversgveacktavhnllaqrvsgliinyplddqdaiaveaactnvpalfldvsdqtpinsiifshedgtrlgvehlvalghqqiallagplssvsarlrlagwhkyltrnqiqpiaeregdwsamsgfqqtmqmlnegivptamlvandqmalgamraitesglrvgadisvvgyddtedsscyipplttikqdfrllgqtsvdrllqlsqgqavkgnqllpvslvkrkttla
interface signature	LYSYQSRHALA

Estimated binding specificities ?

readout + contact

# IC=8.912 IC/col=0.990 n_of_columns=9

specificity:

A |   9   0   0   0   0  73   7   0   7
C |   7   0   0   0   0   7   9  96   9
G |   7   0  96   0  96   7  73   0  73
T |  73  96   0  96   0   9   7   0   7

scan!

Dendrogram of similar interfaces ?

matrix format

  
  LTYCSGYGQC--STRG--HT--AG--LGAC   L                              +1efa_B    
                                                        +---------2 
  ITYTSGMTAA--STRG--NT--AG--LCAT   L                    !         ! +3oqm_C    
                                                  +-----3         +-1 
  IT--ST--ATTTSTRG----VTAG--LCAC                  !     !           +1rzr_C    
                                       +----------4     ! 
  ----SG--TC------RG--------LCKA   L   !          !     +----------1jft_A    
                                     --5          ! 
  LT----ITTGTTST----DCIT--LCRT--   L   !          +----------------7ce1_D    
                                       ! 
  --YT--YTQATTSTRT--HG------RT--       +---------------------------1osl_A

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updated Tue Dec 19 05:33:22 2023