interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF A CREB BZIP-CRE COMPLEX REVEALS THE BASIS FOR CREB FAIMLY SELECTIVE DIMERIZATION AND DNA BINDING
(TRANSCRIPTION FACTOR CREB)
referenceSchumacher et al. J.Biol.Chem. 275 35242 2000
sourceMus musculus
experimentX-ray (resolution=3.00, R-factor=0.218)
structural superfamilyLeucine zipper domain;
sequence familybZIP transcription factor; Basic region leucine zipper;
multimeric complexes1dh3_AC 5zk1_AC 5zko_ACGH
redundant complexes5zk1 5zko
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNAASR

Estimated binding specificities ?

contactlogo
# IC=2.674 IC/col=0.535 n_of_columns=5 specificity:   
A |   9   9  24   9  96
C |  69  11  24  67   0
G |   9  67  24  11   0
T |   9   9  24   9   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: CREB
TGACGTCAPubMed1dh3_C(1.78e-03), 1dh3_AC(2.83e-10), 5zko_ACGH(6.61e-12)
TGACGPubMed1dh3_C(1.35e-04), 1dh3_AC(1.76e-06), 5zk1_AC(1.02e-03), ... (total=4)
CGTCAPubMed1dh3_C(1.35e-04), 1dh3_AC(1.76e-06), 5zk1_AC(1.02e-03), ... (total=4)
TGACATCAPubMed1dh3_AC(1.26e-05), 5zko_ACGH(5.71e-07)
TGACGTPubMed1dh3_C(3.57e-04), 1dh3_AC(1.88e-05), 5zk1_AC(3.41e-03), ... (total=4)
CGGAAGTGACGTCACPubMed1dh3_C(1.25e-02), 1dh3_AC(2.06e-07), 5zko_ACGH(3.17e-06)
ATGACGTCATPubMed1dh3_C(4.09e-03), 1dh3_AC(8.38e-09), 5zko_ACGH(5.16e-09)
GTGACGTACPubMed1dh3_C(2.94e-03), 1dh3_AC(1.58e-03), 5zko_ACGH(2.67e-04)
AGATGATGTAAPubMed5zko_ACGH(2.32e-03)
TGACCTCAPubMed1dh3_AC(1.26e-05), 5zko_ACGH(5.71e-07)
TGAGGTCAPubMed1dh3_AC(1.26e-05), 5zko_ACGH(5.71e-07)
GTCATPubMed1dh3_AC(1.77e-03), 5zko_ACGH(7.13e-03)
TAACGTTAPubMed1dh3_AC(1.31e-02), 5zko_ACGH(1.23e-03)
CGGAAGTGACGTCAPubMed1dh3_C(1.01e-02), 1dh3_AC(1.22e-07), 5zko_ACGH(1.40e-06)
TGGCGPubMed1dh3_C(1.35e-04), 1dh3_AC(1.87e-03)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format
  
  ------RA----NA--AAVT--STRG--   L                               +1h89_A    
                                                               +-1 
  ------------RG----NC--YGATRC   L           +-----------------3 +4eot_A    
                                             !                 ! 
  ----RG------NC--YGAT--CTRG--   L           !                 +2wt7_B    
                                             ! 
  ------------NT--ATAT--STRG--   L           !                 +1dh3_C    
                                     +-------8             +---4 
  RA----NA----AAVT--STRG------   L   !       !             !   ! +1nwq_C    
                                     !       !           +-6   +-2 
  --AAVT----STRG--------------   L   !       !           ! !     +1hjb_A    
                                     !       !           ! ! 
  --QC----FTRC----------------   L --9       +-----------7 +----7aw7_D    
                                     !                   ! 
  ------NC----AT----STRA------       !                   !    +-1a02_J    
                                     !                   +----5 
  ------------NCTT--AT----RG--   L   !                        +-2dgc_A    
                                     ! 
  ----NCRT--ATAT--STRG--------       +--------------------------1t2k_D

home
updated Tue Dec 19 05:32:04 2023